Data-Driven Optimization of Au Nanoparticle Synthesis with Automated Flow Microreaction System

We developed a flow microreaction system automated by LabVIEW-based program enabling control of rates four pumps, an in-line UV–visible spectroscopic monitoring, and process data logging including the pump pressures. The was applied to synthesis gold nanoparticles (NPs) reduction hydrogen tetrachloroaurate (III) (HAuCl4) with sodium tetrahydroborate (NaBH4) in presence trisodium citrate (Na3C6H5O7). Concentrations three reagents were controlled changing optimized so that spectrum NPs gave higher peak at shorter wavelength. A gradual change concentrations from dilute condition according decision-tree algorithm as well careful monitoring pressures shown be effective for optimization without clogging particles reactor.